Anti- Piezo1 Antibody | FNab06435

Anti- Piezo1 Antibody | FNab06435 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678) . Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066) . In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035) . Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity) .

Immunogen: family with sequence similarity 38, member A

synonyms: FAM38A, KIAA0233

Molecular weight (observed) : 250kd

Reactivity Species: Human, Mouse

Tested Application: ELISA, IHC, WB, IP, IF

Recomended Dillution : WB: 1:200-1:1000; IHC: 1:50-1:500

Research Area: N/A