Anti-PRKAR1A (PKA regulatory subunit I alpha) monoclonal Antibody | MB62373

Anti-PRKAR1A (PKA regulatory subunit I alpha) monoclonal Antibody | MB62373 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Mouse, Rat

Application: IF, IHC, WB

Application Range: WB 1:2000, IHC 1:50, IF 1:100

Background: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC) . This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40) . Three alternatively spliced transcript variants encoding the same protein have been observed.

Storage & Stability: PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Specificity: protein kinase cAMP-dependent type I regulatory subunit alpha

Molecular Weight: 43.0 kDa (Predicted)

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: ACRDYS1; ADOHR; CAR; CNC; CNC1; PKR1; PPNAD1; PRKAR1; TSE1

Immunogen: Full-length protein expressed in 293T cell transfected with human PRKAR1A expression vector

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Pathway: N/A