Anti-PVRIG Antibody | A2247

Poliovirus receptor-related immunoglobulin domain-containing (PVRIG), also known as CD112 receptor (CD112R), is a 34 kDa transmembrane protein that belongs to the poliovirus receptor-like protein family. It is expressed on T cells and NK cells, but not on monocytes, neutrophils, and B cells. PVRIG binds with high affinity to poliovirus receptor-related 2 (PVRL2/CD112/Nectin-2) and inhibits T-cell mediated immune responses. Expression of PVRIG on T cells is high in multiple cancers such as lung, kidney, breast, ovarian, and endometrial cancers. Blocking of PVRIG alone or in combination with other immune checkpoint proteins such as TIGIT and PD-1 has been demonstrated to increase the production of cytokines and T-cell mediated cytotoxic activity. A novel monoclonal antibody (COM701) has been demonstrated to disrupt the interaction between PVRIG and PVRL2, thus inhibiting tumor growth.

A2247 | Anti-PVRIG Antibody DataSheet

Antibody Target: PVRIG

Target Alternative Name: CD112R, C7orf15, PVRIG, MGC2463, CD112 Receptor, Nectin-2 Receptor

Tag Line: Rabbit polyclonal antibody to detect PVRIG expression in human and mouse samples

Category: Primary antibody

Host: Rabbit

Isotype: IgG

Species Reactivities: Mouse,Human

Immunogen Sequence: Recombinant Human Transmembrane protein PVRIG protein (193 - 326 aa)

Accession #: Q6DKI7

Gene ID: 79037

Appearance: Colorless liquid

Form: Liquid

Concentration:

Formulation: In 0.01 M PBS, pH 7.4, 50% Glycerol, 0.03% proclin 300

Purification: Protein G purified

Application: Immunofluorescence (IF),Western Blotting

Positive Control:

Application And Usages: WB 1:1000-1:5000, IF 1:50-1:200

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: TRUE

Immunocytochemistry Verified: FALSE

Immunofluorescence Verified: TRUE

Immunoprecipitation Verified: FALSE

FACS Verified: FALSE

ELISA Verified: FALSE

ChIP Verified: FALSE

Dot Blot Verified: FALSE

Flow Cytometry Verified: FALSE