Anti-Pyruvate Dehydrogenase E2 Polyclonal Antibody | A2336

The multi-component pyruvate dehydrogenase complex is a group of enzymes in the inner mitochondrial membrane that catalyzes the conversion of pyruvate into acetyl coenzyme A and links glycolysis to the Krebs cycle in cellular respiration. The E2 component, also known as dihydrolipoamide acetyltransferase, accepts the acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to conezyme A. The E2 component is an antigen for antimitochondrial antibodies, which are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis. Disruptions in the E2 gene can cause a deficiency in E2 protein, which can in turn cause primary lactic acidosis in infancy and early childhood.

A2336 | Anti-Pyruvate Dehydrogenase E2 Polyclonal Antibody DataSheet

Antibody Target: Human pyruvate dehydrogenase E2

Target Alternative Name: Dihydrolipoamide S-Acetyltransferase; PDC-E2; PDCE2; DLTA; PBC; E2; DLAT

Tag Line: Part of the pyruvate dehydrogenase complex that catalyzes the conversion of pyruvate to acetyl CoA

Category: GM-CSF

Host: Rabbit

Isotype: Rabbit IgG

Species Reactivities: Mouse Rat Human

Immunogen Sequence: Recombinant fusion protein of human pyruvate dehydrogenase E2

Accession #: P10515

Gene ID: 1737

Appearance: Liquid

Form: Rabbit IgG

Concentration:

Formulation: In PBS with 0.02% sodium azide, 50% glycerol, pH 7.3

Purification: Affinity purification

Application: Immunofluorescence (IF) Immunohistochemistry (IHC) Western Blotting

Positive Control:

Application And Usages:

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: FALSE

Immunocytochemistry Verified: TRUE

Immunofluorescence Verified: FALSE

Immunoprecipitation Verified: TRUE

FACS Verified: FALSE

ELISA Verified: FALSE

ChIP Verified: TRUE

Dot Blot Verified: FALSE

Flow Cytometry Verified: FALSE