Anti- RAIDD Antibody | FNab07092

Anti- RAIDD Antibody | FNab07092 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: RAIDD, also named as CRADD, is an apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex. CRADD interacts with BCL10 through its caspase recruitment domain and suppresses interactions between BCL10 and CARMA1. It is a negative regulator of the CARMA1 signalosome and suppressor of Th1-and Th17-mediated inflammatory responses.

Immunogen: CASP2 and RIPK1 domain containing adaptor with death domain

synonyms: CRADD, RAIDD

Molecular weight (observed) : 23 kDa

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, WB, IF, IP

Recomended Dillution : WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:20-1:200

Research Area: Signal Transduction, Metabolism