Anti-Rat CD45 Monoclonal Antibody (APC Conjugated) | DL22310F

Anti-Rat CD45 Monoclonal Antibody (APC Conjugated) | DL22310F | Gentaur UK, US & Europe Distribution

Host: Mouse

Synonyms: Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, LCA, T200, Ly-5, Ptprc

Reactivity: Rat

Application: FCM

Background: CD45 is a 180-220 kD protein also known as leukocyte common antigen (LCA) . It is a protein tyrosine phosphatase with multiple isoforms differing as a result of alternative splicing of the extracellular domain and glycosylation. CD45 is expressed on all hematopoietic cells except erythrocytes and platelets; isoform expression depends on cell type, activation state, and cell maturation. CD45 functions in signal transduction through T and B cell antigen receptors. CD45 has been shown to interact with various proteins including galectin-1, CD2, CD3, and CD4. The OX-1 antibody has been shown to partially inhibit NK cell-mediated lysis of syngeneic tumor cells in vitro.

Concentration: 0.2 mg/mL

Conjugation: APC

Buffer: PBS with 0.05% Proclin300, 1% BSA

Clone: OX-1

Isotype: Mouse IgG1, κ