Anti-RIC8A (RIC8) monoclonal Antibody | MB62394

Anti-RIC8A (RIC8) monoclonal Antibody | MB62394 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Mouse, Rat

Application: IF, IHC, WB

Application Range: WB 1:1000, IHC 1:50, IF 1:100

Background: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G (i) -alpha protein, possibly leading to release G (i) -alpha-GTP and NuMA proteins from the NuMA-GPSM2-G (i) -alpha-GDP complex (By similarity) . Also acts as an activator for G (q) -alpha (GNAQ) protein by enhancing the G (q) -coupled receptor-mediated ERK activation

Storage & Stability: PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Specificity: RIC8 guanine nucleotide exchange factor A

Molecular Weight: 59.6 kDa (Predicted)

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: RIC8

Immunogen: Full length human recombinant protein of human RIC8A (NP_068751) produced in HEK293T cell.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Pathway: N/A