Anti- RIP3 Antibody | FNab07312

Anti- RIP3 Antibody | FNab07312 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

Immunogen: receptor-interacting serine-threonine kinase 3

synonyms: Receptor interacting protein 3, RIP 3, RIP like protein kinase 3, RIP3, RIPK3

Molecular weight (observed) : 57 kDa

Reactivity Species: Human, Mouse

Tested Application: ELISA, WB, IHC, IF, IP

Recomended Dillution : WB: 1:200-1:1000; IP: 1:200-1:1000; IHC: 1:100-1:400

Research Area: Signal Transduction, Metabolism