Anti-SARS-CoV-2 Envelope (E) Antibody | A2261

Coronaviruses are large, enveloped, positive-sense RNA viruses that affect humans and a wide variety of mammals. These viruses have a genome length of 30 kb. The 5'-terminal of the viral genome encodes 2 polyproteins that cleave to yield several non-structural proteins. The 3'-terminal encodes 4 structural proteins, namely, Spike (S), Envelope (E), Membrane (M), and Nucleocapsid (N). Coronavirus envelope (E) proteins are short (100 residues) polypeptides that contain at least one transmembrane (TM) domain and a cluster of 2-3 juxtamembrane cysteines. These proteins are involved in viral morphogenesis and tropism, and their absence in some cases leads to aberrant virions or viral attenuation. The Envelope protein increases membrane permeability to ions and plays a central role in virus morphogenesis and assembly. It acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. It also plays a role in the induction of apoptosis. Envelope protein also activates the host NLRP3 inflammasome, leading to IL-1 beta overproduction.

A2261 | Anti-SARS-CoV-2 Envelope (E) Antibody DataSheet

Antibody Target: Envelope (E)

Target Alternative Name: 2019-nCoV E protein, 2019-nCoV sM protein, Envelope small membrane protein, Envelope protein

Tag Line: Rabbit polyclonal antibody to detect SARS-CoV-2 Envelope (E) protein

Category: Primary antibody

Host: Rabbit

Isotype: IgG

Species Reactivities: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Immunogen Sequence: Recombinant SARS-CoV-2 E protein

Accession #: P0DTC4

Gene ID:

Appearance: Colorless liquid

Form: Liquid

Concentration:

Formulation: In PBS, pH 7.4, 50% glycerol, 0.05% proclin 300

Purification:

Application:

Positive Control:

Application And Usages:

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: FALSE

Immunocytochemistry Verified: FALSE

Immunofluorescence Verified: FALSE

Immunoprecipitation Verified: FALSE

FACS Verified: FALSE

ELISA Verified: FALSE

ChIP Verified: FALSE

Dot Blot Verified: FALSE

Flow Cytometry Verified: FALSE