Anti-SARS-CoV-2 ORF7a Antibody | A2259

Severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) is an infectious disease caused by a novel beta-coronavirus called SARS-CoV-2. The SARS-CoV-2 is a large enveloped, positive-sense RNA with a genome about ~ 30 kb long. The genome encodes 11 open reading frames. The open reading frame ORF7a is a type I transmembrane protein that codes for viral non-structural (accessory) proteins of unknown function. It is localized to the Golgi apparatus but may also be found on cell surfaces. In comparison with ORF7a of SARS-CoV, it has a sequence identity of 85.2% and a sequence similarity of 95.9%. Due to overlap with ORF7b, ORF7a shares a transcriptional regulatory sequence. ORF7a possesses a 15 amino acid N-terminal signal peptide, an 81 amino acid luminal domain, a 21 amino acid transmembrane domain, and a 5 amino acid cytoplasmic tail. A recent study demonstrated that SARS-CoV ORF7a acts as an antagonist to Bone marrow stromal antigen 2 (BST-2) antiviral activities. ORF7a extracellular domain binds to the unglycosylated extracellular domain of BST-2 in the Golgi apparatus and prevents N-linked glycosylation that is necessary for BST-2 antiviral activity.

A2259 | Anti-SARS-CoV-2 ORF7a Antibody DataSheet

Antibody Target: ORF7a

Target Alternative Name: ORF7a, Accessory protein 7a, Protein U122, Protein X4, ORF7a protein

Tag Line: Rabbit polyclonal antibody to detect SARS-CoV-2 ORF7a protein

Category: Primary antibody

Host: Rabbit

Isotype: IgG

Species Reactivities: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Immunogen Sequence: Amino acids 1-100 of ORF7a protein

Accession #: P0DTC7

Gene ID:

Appearance: Colorless liquid

Form: Liquid

Concentration:

Formulation: In PBS, pH 7.4, 50% glycerol, 0.05% proclin 300

Purification:

Application:

Positive Control:

Application And Usages:

Country of Animal Origin: USA

Country of Manufacture: USA

Usage: For Research Use Only! Not to be used in humans.

Handling: The antibody solution should be gently mixed before use.

Western Blot Verified: FALSE

Immunocytochemistry Verified: FALSE

Immunofluorescence Verified: FALSE

Immunoprecipitation Verified: FALSE

FACS Verified: FALSE

ELISA Verified: FALSE

ChIP Verified: FALSE

Dot Blot Verified: FALSE

Flow Cytometry Verified: FALSE