Anti-SLC7A8 (LAT2) monoclonal Antibody | MB62412

Anti-SLC7A8 (LAT2) monoclonal Antibody | MB62412 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Mouse, Rat

Application: FC, IF, IHC, IP, WB

Application Range: WB 1:500, IHC 1:50, IF 1:100, FLOW 1:100, IP 2ug/500ul

Background: Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re) absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine orD,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.

Storage & Stability: PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Specificity: solute carrier family 7 member 8

Molecular Weight: 58.4 kDa (Predicted)

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: LAT2; LPI-PC1

Immunogen: Full-length protein expressed in 293T cell transfected with human SLC7A8 expression vector .

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Pathway: N/A