Anti- STIM1 Antibody | FNab08320

Anti- STIM1 Antibody | FNab08320 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: STIM1, also named as GOK, is an ER Ca2+ sensor. Upon Ca2+ store depletion, STIM1 clusters at ER–plasma membrane junctions where it interacts with and gates Ca2+-permeable Orai1 ion channels. STIM1 is implicated in tumor growth suppression and stromal-haematopoietic cell interactions. Defacts in STIM1 gene can cause immune dysfunction with impaired T-cell activation. STIM1 can inhibit L-type voltage-gated Ca (2+) channels in neurons. Temperature is an important regulator of STIM1 function.The MW of STIM1 is about 80-90 kDa which may be due to the phosphorylation or glycosylation forms. This antibody is rabbit polyclonal antibody raised against the N-terminal of human STIM1.

Immunogen: stromal interaction molecule 1

synonyms: D11S4896E, GOK, STIM1, stromal interaction molecule 1

Molecular weight (observed) : 80kd

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IP

Recomended Dillution : WB: 1:500-1:1000; IP: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100

Research Area: Neuroscience, Immunology