Anti- TRADD Antibody | FNab10260

Anti- TRADD Antibody | FNab10260 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity) . Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.

Immunogen: TNFRSF1A-associated via death domain

synonyms: Hs.89862, TRADD

Molecular weight (observed) : 34 kDa, 27 kDa

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, IHC, WB

Recomended Dillution : WB: 1:200 - 1:2000; IHC: 1:50 - 1:500

Research Area: Signal Transduction