Anti- TRPV4 Antibody | FNab09028

Anti- TRPV4 Antibody | FNab09028 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:18826956, PubMed:18695040) . Also activated by heat, low pH, citrate and phorbol esters (PubMed:18826956, PubMed:18695040) . Increase of intracellular Ca (2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (PubMed:12724311, PubMed:18826956) . Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers (By similarity) . Acts as a regulator of intracellular Ca (2+) in synoviocytes (PubMed:19759329) . Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12, 13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (PubMed:19759329) . Together with PKD2, forms mechano-and thermosensitive channels in cilium (PubMed:18695040) . Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes (By similarity) . Regulates expression of chemokines and cytokines related to proinflammatory pathway in adipocytes (By similarity) . Together with AQP5, controls regulatory volume decrease in salivary epithelial cells (By similarity) .

Immunogen: transient receptor potential cation channel, subfamily V, member 4

synonyms: Osm 9 like TRP channel 4, OTRPC4, TRP12, TRPV4, VR OAC, VRL 2, VRL2, VROAC

Molecular weight (observed) : 98 kDa

Reactivity Species: Human, Mouse

Tested Application: ELISA, IHC

Recomended Dillution : WB: 1:500-1:2000

Research Area: Epigenetics, Metabolism