710
Anti- TRPV6 Antibody | FNab09030
- SKU:
- 710-FNab09030-GEN
- Availability:
- In Stock - Delivery within a week
Description
Anti- TRPV6 Antibody | FNab09030 | Gentaur UK, US & Europe Distribution
Form: liquid
Purification: Immunogen affinity purified
Purity: ≥95% as determined by SDS-PAGE
Host: Rabbit
Clonality: polyclonal
Clone ID: N/A
Isotype: IgG
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Background: Calcium selective cation channel that mediates Ca (2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11278579, PubMed:11248124 PubMed:15184369, PubMed:23612980) . Important for normal Ca (2+) ion homeostasis in the body, including bone and skin (By similarity) . The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369) . Inactivation includes both a rapid Ca (2+) -dependent and a slower Ca (2+) -calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg (2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.
Immunogen: transient receptor potential cation channel, subfamily V, member 6
synonyms: ABP/ZF, Calcium transport protein 1, CaT L, CaT like, CAT1, CATL, ECAC2, Epithelial calcium channel 2, HSA277909, LP6728, TRPV6, ZFAB
Molecular weight (observed) : 82 kDa, 70 kDa
Reactivity Species: Human, Mouse, Rat
Tested Application: ELISA, IF
Recomended Dillution : WB: 1:500-1:5000; IP: 1:200-1:1000; IF: 1:10-1:100
Research Area: Cancer