Anti- UCHL1/PGP9.5 Antibody | FNab09218

Anti- UCHL1/PGP9.5 Antibody | FNab09218 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: UCHL1 (Ubiquitin carboxyl-terminal hydrolase isozyme L1) is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCHL1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It is present in all neurons (PMID: 6343558) . This protein is present in brain at concentrations at least 50 times greater than in other organs and is a major protein component of neuronal cytoplasm (PMID:7217993) . And UCHL1 is a Parkinson's disease susceptibility gene (PMID:15048890) .

Immunogen: ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

synonyms: Neuron cytoplasmic protein 9.5, PARK5, PGP 9.5, PGP9.5, Ubiquitin thioesterase L1, Uch L1, UCHL1

Molecular weight (observed) : 26 kDa

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF

Recomended Dillution : WB: 1:500-1:5000; IHC：1:100-1:500; IP: 1:1000-1:5000

Research Area: Neuroscience, Cancer, Metabolism, Epigenetics