Anti- uPAR Antibody | FNab09268

Anti- uPAR Antibody | FNab09268 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Urokinase plasminogen activator surface receptor (uPAR, also known as PLAUR or CD87) is a 45-65 kDa, highly glycosylated, GPI-anchored membrane protein. It contains three homologous domains (D1-D3) of which the N-terminal one (D1) represents the uPA-binding domain. After binding to uPAR, urokinase plasminogen activator (uPA) cleaves plasminogen, generating the active protease plasmin which is involved in a wide variety of physiologic and pathologic processes. In addition to regulating proteolysis, uPAR has important function in cell adhesion, migration and proliferation. Studies reveal that uPAR expression is elevated during inflammation and tissue remodelling and in many human cancers, in which it frequently indicates poor prognosis. (PMID 20027185; 12461559)

Immunogen: plasminogen activator, urokinase receptor

synonyms: CD87, MO3, PLAUR, U PAR, UPAR, URKR

Molecular weight (observed) : 37-70 kDa

Reactivity Species: Human, Mouse

Tested Application: ELISA, WB, IHC, IP, IF

Recomended Dillution : WB: 1:200-1:2000; IP: 1:200-1:1000

Research Area: Immunology, Cardiovascular, Signal Transduction