Anti- USP11 Antibody | FNab09306

Anti- USP11 Antibody | FNab09306 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:24724799) . Inhibits the degradation of target proteins by the proteasome (PubMed:12084015) . Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro) (PubMed:24724799) . Plays a role in the regulation of pathways leading to NF-kappa-B activation (PubMed:17897950, PubMed:19874889) . Plays a role in the regulation of DNA repair after double-stranded DNA breaks (PubMed:15314155, PubMed:20233726) .

Immunogen: ubiquitin specific peptidase 11

synonyms: Deubiquitinating enzyme 11, Ubiquitin thiolesterase 11, UHX1, USP11

Molecular weight (observed) : 110 kDa

Reactivity Species: Human

Tested Application: ELISA, WB, IHC, IP, IF

Recomended Dillution : WB: 1:500-1:1000; IP: 1:200-1:1000; IHC: 1:50-1:500

Research Area: Epigenetics, Metabolism