Anti- WRAP53 Antibody | FNab09523

Anti- WRAP53 Antibody | FNab09523 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for telomerase activity. Binds small Cajal body RNAs (scaRNAs) . The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post-transcriptional level; it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage.

Immunogen: WD repeat containing, antisense to TP53

synonyms: FLJ10385, TCAB1, WDR79, WRAP53

Molecular weight (observed) : 72 kDa

Reactivity Species: Human, Mouse, Rat

Tested Application: ELISA, WB, IP

Recomended Dillution : WB: 1:500-1:5000; IHC: 1:20-1:200; IP: 1:200-1:1000

Research Area: Metabolism