Anti- WWP2 Antibody | FNab09535

Anti- WWP2 Antibody | FNab09535 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.

Immunogen: WW domain containing E3 ubiquitin protein ligase 2

synonyms: AIP2, WW domain containing protein 2, WWP2, WWp2 like

Molecular weight (observed) : 120 kDa

Reactivity Species: Human, Mouse

Tested Application: ELISA, WB, IP, IHC, IF

Recomended Dillution : WB: 1:200-1:2000; IHC: 1:20-1:200

Research Area: Epigenetics, Metabolism