Anti- ZW10 Antibody | FNab09760

Anti- ZW10 Antibody | FNab09760 | Gentaur UK, US & Europe Distribution

Form: liquid

Purification: Immunogen affinity purified

Purity: ≥95% as determined by SDS-PAGE

Host: Rabbit

Clonality: polyclonal

Clone ID: N/A

Isotype: IgG

Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)

Background: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131) . Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER) ; the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241) .

Immunogen: ZW10, kinetochore associated, homolog (Drosophila)

synonyms: HZW10, KNTC1AP, ZW10

Molecular weight (observed) : 90 kDa

Reactivity Species: Human

Tested Application: ELISA, WB

Recomended Dillution : WB: 1:500-1:5000; IP: 1:200-1:2000

Research Area: Cell Division and Proliferation, Developmental biology