APC Anti-Mouse CD115 Antibody[AFS98] | E-AB-F1107E

APC Anti-Mouse CD115 Antibody[AFS98] | E-AB-F1107E | Gentaur UK, US & Europe Distribution

Category: Flowcytometry Antibody

Synonyms: Macrophage colony-stimulating factor 1 receptor,CSF-1 receptor (EC:2.7.10.1),CSF-1-R,CSF-1R,M-CSF-R,Proto-oncogene c-Fms,CD115,Csf1r,Csfmr,Fms

Swissprot Code: P09581

Application: FCM

Reactivity: Mouse

Host: Rat

Isotype: Rat IgG2a, κ

Research Areas: Cardiovascular,Immunology,Signal Transduction

Backgroun: CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.

Concentration: N/A

Storage: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.

Immunogen: N/A

Buffer: PBS with 0.05% Proclin300, 1% BSA

Purification Method: N/A

Dilution: N/A

Clone: AFS98

Conjugation: APC

Moleculair Weight(Calculated): N/A

Moleculair Weight(Observed): N/A