APC Anti-Mouse CD200 Antibody[OX-90] | E-AB-F1234UE

APC Anti-Mouse CD200 Antibody[OX-90] | E-AB-F1234UE | Gentaur UK, US & Europe Distribution

Category: Flow Cytometry Antibody

Synonyms: OX-2 membrane glycoprotein,OX-2, MRC

Swissprot Code: O54901

Application: FCM

Reactivity: Mouse

Host: Rat

Isotype: Rat IgG2a, κ

Reaserch Area: Cardiovascular, Immunology

Background: CD200 (OX-2 antigen) is a type-1 membrane glycoprotein containing two extracellular Ig-like domains. CD200 a highly conserved type I membrane glycoprotein that is expressed on a variety of cell types including thymocytes, some T cells, endothelial and follicular dendritc cells, B cells, and brain tissue (neurons); but not on NK cells, granulocytes, monocytes, or macrophages. CD200 costimulates T cell proliferation. It may regulate myeloid cell activity in a variety of tissues. CD200 is the ligand for CD200 receptor (CD200R). The CD200 Receptor is restricted to myeloid cells, and it is believed that its engagement with CD200 results in inhibition and/or downregulation of myeloid cell activity. Blocking of CD200/CD200R interactions decreases myeloid cell inhibitory thresholds which results in enhanced immune activation.

Concentration: 0.2 mg/mL

Storage: Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.

Immunogen: N/A

Purification Method: N/A

Dilution: N/A

Clone: OX-90

Conjugation: APC