APD-597 | 9637

APD-597 is a GPR119 agonist with EC₅₀ of 46 nM for hGPR119. Could be a potential anti-diabetic agent for treatment of type 2 diabetes.

APD-597 is a GPR119 agonist with EC₅₀ of 46 nM for hGPR119. Could be a potential anti-diabetic agent for treatment of type 2 diabetes.

9637 | APD-597 DataSheet

Alternate Name/Synonyms: Propan-2-yl 4-[5-methoxy-6-[(2-methyl-6-methylsulfonylpyridin-3-yl)amino]pyrimidin-4-yl]oxypiperidine-1-carboxylate; JNJ-38431055

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 897732-93-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₉N₅O₆S

Molecular Weight: 479.55

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A second generation agonist of the orphan G-protein coupled receptor GPR119

MDL Number: N/A

PubChem CID: 11691484

SMILES: CC1=C(C=CC(=N1)S(=O)(=O)C)NC2=C(C(=NC=N2)OC3CCN(CC3)C(=O)OC(C)C)OC

InChi: InChI=1S/C21H29N5O6S/c1-13(2)31-21(27)26-10-8-15(9-11-26)32-20-18(30-4)19(22-12-23-20)25-16-6-7-17(24-14(16)3)33(5,28)29/h6-7,12-13,15H,8-11H2,1-5H3,(H,22,23,25)

InChi Key: WPDCHTSXOPUOII-UHFFFAOYSA-N