APEH polyclonal Antibody | BS8085

APEH polyclonal Antibody | BS8085 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB 1:500 - 1:2000

Background: APEH (Acyl-peptide hydrolase), also known as APH, OPH or ACPH, is a 732 amino acid cytoplasmic protein that exists as a homotetramer and functions to catalyze the hydrolysis of N-terminal acetylated amino acids from small acetylated peptides. Once hydrolyzed from the target peptide, the acetyl amino acid is further processed by an aminoacylase to produce acetate and a free amino acid. The gene encoding human APEH maps to a region on chromosome 3 that is deleted in various types of cancers, including renal cell carcinoma and small cell lung carcinoma, suggesting that APEH may be involved in tumor transformation events. Chromosome 3 is made up of about 214 million bases encoding over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: APEH polyclonal Antibody detects endogenous levels of APEH protein.

Molecular Weight: ~ 81 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Acylamino-acid-releasing enzyme; AARE; Acyl-peptide hydrolase; APH; Acylaminoacyl-peptidase; Oxidized protein hydrolase; OPH; APEH; D3F15S2; D3S48E; DNF15S2

Immunogen: Recombinant full length Human APEH.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: