APEX1 Polyclonal Antibody | E-AB-65409

APEX1 Polyclonal Antibody | E-AB-65409 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: APEX1, APE, APE1, APEN, APEX, APX, HAP1, REF1

Application: WB, IF

Reactivity: Human

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling

Background: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant fusion protein of human APEX1 (NP_542380.1).

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000 IF 1:50-1:100

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 35 kDa

Molecular Weight(Observed): 39 kDa