Aphidicolin | B2956

Aphidicolin is a natural tetracyclic diterpene antibiotic which shows antiviral activity against herpes simplex. In eukaryotic cells, it is a cell-permeable, reversible inhibitor of DNA replication, specifically blocking the activity of DNA polymerases α, δ, and ε. It inhibits HeLa DNA polymerases at a concentration of 10 μg/ml. It is used as a cell synchronization agent and blocks the cell cycle at early S-phase.

Aphidicolin is a natural tetracyclic diterpene antibiotic which shows antiviral activity against herpes simplex. In eukaryotic cells, it is a cell-permeable, reversible inhibitor of DNA replication, specifically blocking the activity of DNA polymerases α, δ, and ε. It inhibits HeLa DNA polymerases at a concentration of 10 μg/ml. It is used as a cell synchronization agent and blocks the cell cycle at early S-phase.

B2956 | Aphidicolin DataSheet

Alternate Name/Synonyms: (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-8,11a-methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol; (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-4,9-bis(hydroxymethyl)-4,11b-dimethyltetradecahydro-8,11a-methanocyclohepta[a]naphthalene-3,9-diol; NSC 234714; ICI 69653; NSC 351140

Appearance: Solid

Formulation:

CAS Number: 38966-21-1

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₂₀H₃₄O₄

Molecular Weight: 338.48

Cell-Permeable?: True

Purity: ≥98%

Solubilities: ~50 mg/ml in in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of DNA polymerases α, δ, and ε Aphidicolin and an antibiotic

MDL Number: MFCD00083214

PubChem CID: 457964

SMILES: CC12CCC(C(C1CCC3C24CCC(C(C3)C4)(CO)O)(C)CO)O

InChi: InChI=1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1

InChi Key: NOFOAYPPHIUXJR-APNQCZIXSA-N