Apigenin | 2508

A naturally occurring plant flavone that displays remarkable anti-inflammatory, antioxidant and anti-carcinogenic properties. It selectively inhibits casein kinase II (CK2). Apigenin inhibits CK2 activity in the renal cortex with an IC₅₀ value of 30 µM to improve renal function in a rat model of glomerulonephritis. CK2 inhibition by 20 µM apigenin decreases the degradation of IκBα and down-regulates NF-κB levels in WEHI 231 cells. At 5 µM, it is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression by 56% and 64%, respectively, in the macrophage cell line J774A.1.

Apigenin is a naturally occurring plant flavone that displays remarkable anti-inflammatory, antioxidant and anti-carcinogenic properties. It selectively inhibits casein kinase II (CK2). Apigenin inhibits CK2 activity in the renal cortex with an IC₅₀ value of 30 µM to improve renal function in a rat model of glomerulonephritis.

2508 | Apigenin DataSheet

Alternate Name/Synonyms: 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; Chamomile; Flavone; NSC 83244; Versulin

Appearance: White solid

Formulation: N/A

CAS Number: 520-36-5

Structure Available?: Yes

Peptide sequence: No

Salt Form: No

Molecular Formula: C₁₅H₁₀O₅

Molecular Weight: 270.2

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A casein kinase II (CKII) inhibitor

MDL Number: MFCD00006831

PubChem CID: 5280443

SMILES: C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O

InChi: InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H

InChi Key: KZNIFHPLKGYRTM-UHFFFAOYSA-N