APIP Antibody (Center) [ApR04995G]

APIP Antibody (Center) [ApR04995G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This APIP antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 111-142 amino acids from the Central region of human APIP.

Cellular Localisation: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03116, ECO:0000269|PubMed:15262985, ECO:0000269|PubMed:23285211}

Molecular Weight: 27125

Clone: Polyclonal

Gene Name: APIP {ECO:0000255|HAMAP-Rule:MF_03116}

Gene ID: 51074

Function: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2, 3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) . Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.

Summary: Tissue Location: Isoform 1 is ubiquitously expressed. Isoform 2 is expressed at lower levels and detected in heart, brain, pancreas, liver, placenta, skeletal muscle and kidney

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB, IHC-P

Dilution: IHC-P--1:100~500 WB--1:2000

Synonyms: Methylthioribulose-1-phosphate dehydratase {ECO:0000255|HAMAP-Rule:MF_03116}, MTRu-1-P dehydratase {ECO:0000255|HAMAP-Rule:MF_03116}, 4.2.1.109 {ECO:0000255|HAMAP-Rule:MF_03116}, APAF1-interacting protein {ECO:0000255|HAMAP-Rule:MF_03116}, hAPIP, APIP {ECO:0000255|HAMAP-Rule:MF_03116}