APOBEC3C Antibody (C-Term) [ApR05014G]

APOBEC3C Antibody (C-Term) [ApR05014G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This APOBEC3C antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 143-177 amino acids from human APOBEC3C.

Cellular Localisation: Nucleus. Cytoplasm

Molecular Weight: 22826

Clone: Polyclonal

Gene Name: APOBEC3C

Gene ID: 27350

Function: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase- dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non- LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.

Summary: Tissue Location: Expressed in spleen, testes, peripherical blood lymphocytes, heart, thymus, prostate and ovary

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: DNA dC->dU-editing enzyme APOBEC-3C, A3C, 3.5.4.-, APOBEC1-like, Phorbolin I, APOBEC3C, APOBEC1L, PBI