ApoJ/Clusterin, mouse recombinant | 7554

Native Apolipoprotein J (ApoJ), also named Clusterin, is a heavily glycosylated, 75-80 kDa disulfide-linked heterodimeric protein. Despite being cloned since 1989, no genuine function has been attributed to ApoJ so far. The protein has been reportedly implicated in several diverse physiological processes such as sperm maturation, lipid transportation, complement inhibition, tissue remodeling, membrane recycling, cell-cell and cell-substratum interactions, stabilization of stressed proteins in a folding-competent state and promotion or inhibition of apoptosis. ApoJ gene is differentially regulated by cytokines, growth factors and stress-inducing agents. Clusterin is up- or down regulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others.

7554 | ApoJ/Clusterin mouse recombinant DataSheet

Biomolecule/Target: ApoJ/Clusterin

Synonyms: TRPM-2, Apolipoprotein J, APO-J, CLI, CLU, SGP-2, AAG4, KUB1, SGP2, SP-40, TRPM2, MGC24903.

Alternates names: Glioma-derived growth factor, GDGF, Osteosarcoma-derived Growth Factor, ODGF, PDGF-AA, PDGF-1, Alpha platelet-derived growth factor receptor, CD140 antigen-like family member A, CD140a antigen, Platelet-derived growth factor alpha receptor

Taglines: A heavily glycosylated protein upregulated in multiple pathological conditions

NCBI Gene ID #: 18590

NCBI Gene Symbol: PDGFA

Gene Source: Mouse

Accession #: P20033

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 97%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <1 EU/g by LAL method

Activity (Specifications/test method): N/A

Biological activity: In progress

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 28.9 kDa

Concentration: 1 mg/ml

Appearance: Liquid

Physical form description: 1 mg/ml of 0.2 m-filtered solution in 55 mM Tris-Cl, pH 8.2, containing 150 mM NaCl.

Reconstitution Instructions: When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile HO to a concentration of 0.1-0.5 mg/ml, which can be further diluted into other aqueous solutions.

Amino acid sequence: N/A