APP Antibody| F43166-0.4ML/R33373-100UG

APP Antibody| F43166-0.4ML/R33373-100UG | Gentaur UK, US & Europe Distribution

Background: The APP gene encodes Amyloid beta, a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: N/A

Application: IF, IHC, WB, ELISA

Application Details: Western blot: 1:1000, Immunofluorescence: 1:10-1:50, IHC (Paraffin): 1:10-1:50

Application Note: Titration of the anti-APP antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This anti-APP antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 333-362 from the human protein was used as the immunogen for this anti-APP antibody.

Storage: Aliquot the anti-APP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A