APPL1 Antibody | 19-426

APPL1 Antibody | 19-426 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human APPL1 (NP_036228.1) .

Research Area: Apoptosis, Cell Cycle, Neuroscience, Signal Transduction

Tested Application: WB

Application: WB: 1:500 - 1:2000

Specificiy: N/A

Positive Control 1: SKOV3

Positive Control 2: SH-SY5Y

Positive Control 3: 293T

Positive Control 4: HL-60

Positive Control 5: Mouse brain

Positive Control 6: Mouse lung

Molecular Weight: Observed: 95kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: APPL1, APPL, adaptor protein containing pH domain, PTB domain and leucine zipper motif, PTB domain and leucine zipper motif 1, DIP13alpha, APPL1, signaling adaptor protein DIP13alpha, AKT2 interactor, adaptor protein, phosphotyrosine interaction, PH domai

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.