APY-0201 | 9564

APY0201 is a potent, highly selective, ATP-competitive PIKfyve inhibitor (IC₅₀ = 5.2 nM) that interrupts the conversion of phosphatidylinositol 3-phosphate (PtdIns3P) to PtdIns(3,5)P2. Also acts as a unique small molecular IL-12/23 production inhibitor.

APY0201 is a potent, highly selective, ATP-competitive PIKfyve inhibitor (IC₅₀ = 5.2 nM) that interrupts the conversion of phosphatidylinositol 3-phosphate (PtdIns3P) to PtdIns(3,5)P2. Also acts as a unique small molecular IL-12/23 production inhibitor.

9564 | APY-0201 DataSheet

Alternate Name/Synonyms: (E)-4-(5-(2-(3-methylbenzylidene)hydrazinyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1232221-74-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₃N₇O

Molecular Weight: 413.48

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, highly selective, ATP-competitive PIKfyve inhibitor

MDL Number: N/A

PubChem CID: 70941637

SMILES: CC1=CC=CC(=C1)C=NNC2=NC3=CC(=NN3C(=C2)N4CCOCC4)C5=CC=NC=C5

InChi: InChI=1S/C23H23N7O/c1-17-3-2-4-18(13-17)16-25-27-21-15-2

InChi Key: RFZQYGBLRIKROZ-XYGWBWBKSA-N