AQP11 Antibody (C-term) [APR15000G]

AQP11 Antibody (C-term) [APR15000G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This AQP11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 244-271 amino acids from the C-terminal region of human AQP11.

Cellular Localisation: Cytoplasmic vesicle membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm {ECO:0000250|UniProtKB:Q8BHH1}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8BHH1}. Note=Localizes mainly to the periphery of lipid droplets (PubMed:24845055) . it accumulates partly in mitochondrial-associated endoplasmic reticulum membranes (PubMed:31546170) .

Molecular Weight: 30203

Clone: Polyclonal

Gene Name: AQP11 (HGNC:19940)

Gene ID: 282679

Function: Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain (PubMed:24845055, PubMed:24918044, PubMed:31546170) . In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway (PubMed:31546170) . Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER (By similarity) . Plays a role in the proximal tubule function by regulating its endosomal acidification (By similarity) . May play a role in postnatal kidney development (By similarity) .

Summary: Tissue Location: Detected in the sperm head and tail (at protein level) (PubMed:28042826) . Expressed in subcutaneous adipocytes (PubMed:24845055) . Expressed in testis, kidney and ejaculated spermatozoa (PubMed:19812234) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: FC, WB

Dilution: WB--1:2000 FC--1:10~50

Synonyms: Aquaporin-11, AQP-11, AQP11, AQPX1