AQP3 Antibody (Center) [APG01965G]

AQP3 Antibody (Center) [APG01965G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This AQP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-191 amino acids from the Central region of human AQP3.

Cellular Localisation: Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P47862}. Basolateral cell membrane {ECO:0000250|UniProtKB:P47862}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P47862}

Molecular Weight: 31544

Clone: Polyclonal

Gene Name: AQP3

Gene ID: 360

Function: Water channel required to promote glycerol permeability and water transport across cell membranes (PubMed:12239222, PubMed:30420639) . Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity) .

Summary: Tissue Location: Widely expressed in epithelial cells of kidney (collecting ducts) and airways, in keratinocytes, immature dendritic cells and erythrocytes. Isoform 2 is not detectable in erythrocytes at the protein level

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:500 WB--1:2000 WB--1:1000

Synonyms: Aquaporin-3, AQP-3, Aquaglyceroporin-3, AQP3