AQP5 Antibody (C-term) [APG01967G]

AQP5 Antibody (C-term) [APG01967G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This AQP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227-256 amino acids from the C-terminal region of human AQP5.

Cellular Localisation: Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein Note=Hypotonicity increases location at the cell membrane Phosphorylation decreases location at the cell membrane

Molecular Weight: 28292

Clone: Polyclonal

Gene Name: AQP5

Gene ID: 362

Function: Forms a water-specific channel (PubMed:8621489, PubMed:18768791) . Plays an important role in fluid secretion in salivary glands (By similarity) . Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723) . Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity) .

Summary: Tissue Location: Detected in skin eccrine sweat glands, at the apical cell membrane and at intercellular canaliculi (at protein level) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, FC

Dilution: FC--1:25 WB--1:2000

Synonyms: Aquaporin-5, AQP-5, AQP5