Aramchol | B3027

Aramchol is a conjugate of cholic acid and arachidic acid. It is a synthetic fatty-acid/bile-acid conjugate (FABAC). It significantly reduces hepatic fat content in a high fat diet animal model. It dissolves pre-existing cholesterol crystals in model bile solutions. It causes 70% to 83% inhibition of stearoyl coenzyme A desaturase 1 (SCD1) activity in vitro. Aramchol (0.5 mg or 1.0 mg/d) reduces the development of gallstones or cholesterol crystals in mice fed a lithogenic high-fat diet. It significantly reduces liver fat content in patients with nonalcoholic fatty liver disease.

Aramchol is a conjugate of cholic acid and arachidic acid. It is a synthetic fatty-acid/bile-acid conjugate (FABAC). It significantly reduces hepatic fat content in a high fat diet animal model. It dissolves pre-existing cholesterol crystals in model bile solutions. It causes 70% to 83% inhibition of stearoyl coenzyme A desaturase 1 (SCD1) activity in vitro. Aramchol (0.5 mg or 1.0 mg/d) reduces the development of gallstones or cholesterol crystals in mice fed a lithogenic high-fat diet. It significantly reduces liver fat content in patients with nonalcoholic fatty liver disease.

B3027 | Aramchol DataSheet

Alternate Name/Synonyms: (4R)-4-[(3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-dihydroxy-3-(icosanoylamino)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid; 3beta-arachidylamido-7alpha,12alpha-dihydroxy-5beta-cholan-24-oic acid; C20-FABAC; (3beta,5beta,7alpha,12alpha)-7,12-dihydroxy-3-(icosanoylamino)cholan-24-oic acid

Appearance: White Solid

Formulation:

CAS Number: 246529-22-6

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₄₄H₇₉NO₅

Molecular Weight: 702.1

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~20 mg/ml in ethanol and DMSO, ~30 mg/ml in DMF

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A synthetic fatty-acid/bile-acid conjugate (FABAC)

MDL Number: MFCD21608618

PubChem CID: 18738120

SMILES: CCCCCCCCCCCCCCCCCCCC(=O)NC1CCC2(C(C1)CC(C3C2CC(C4(C3CCC4C(C)CCC(=O)O)C)O)O)C

InChi: InChI=1S/C44H79NO5/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-40(48)45-34-27-28-43(3)33(29-34)30-38(46)42-36-25-24-35(32(2)23-26-41(49)50)44(36,4)39(47)31-37(42)43/h32-39,42,46-47H,5-31H2,1-4H3,(H,45,48)(H,49,50)/t32-,33+,34+,35-,36+,37+,38-,39+,42+,43+,44-/m1/s1

InChi Key: SHKXZIQNFMOPBS-OOMQYRRCSA-N