Arcyriaflavin A | B2902

Arcyriaflavin A inhibits cyclin-dependent kinase 4 (CDK4) with an IC₅₀ of 140 nM. It inhibits calcium/calmodulin-dependent protein kinase II (CaMKII) with an IC₅₀ of 25 nM. It inhibits the replication of human cytomegalovirus (HCMV) in vitro, with an IC₅₀ of 200 nM. It also inhibits proliferation and induces apoptosis of endometriotic stromal cells.

Arcyriaflavin A inhibits cyclin-dependent kinase 4 (CDK4) with an IC₅₀ of 140 nM. It inhibits calcium/calmodulin-dependent protein kinase II (CaMKII) with an IC₅₀ of 25 nM. It inhibits the replication of human cytomegalovirus (HCMV) in vitro, with an IC₅₀ of 200 nM. It also inhibits proliferation and induces apoptosis of endometriotic stromal cells.

B2902 | Arcyriaflavin A DataSheet

Alternate Name/Synonyms: 12,13-Dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione; 6,7,12,13-Tetrahydro-5,7-dioxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole

Appearance: A crystalline solid

Formulation:

CAS Number: 118458-54-1

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₂₀H₁₁N₃O₂

Molecular Weight: 325.32

Cell-Permeable?: True

Purity: ≥95%

Solubilities: ~1 mg/ml in in DMSO, ~5 mg/ml in DMF in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of CDK4 and CaMKII

MDL Number:

PubChem CID: 5327723

SMILES: C1=CC=C2C(=C1)C3=C4C(=C5C6=CC=CC=C6NC5=C3N2)C(=O)NC4=O

InChi: InChI=1S/C20H11N3O2/c24-19-15-13-9-5-1-3-7-11(9)21-17(13)18-14(16(15)20(25)23-19)10-6-2-4-8-12(10)22-18/h1-8,21-22H,(H,23,24,25)

InChi Key: KAJXOWFGKYKMMZ-UHFFFAOYSA-N