Arecoline hydrobromide | B1824

Arecoline is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC₅₀ = 11.1 μM). ACAT2 and DLAT are not inhibited. Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass. Agonist at muscarinic acetylcholine receptors M1 – M5 (EC₅₀ in the range of 7-410 nM). May be effective in dementia.

Arecoline is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC₅₀ = 11.1 μM). ACAT2 and DLAT are not inhibited. Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass. Agonist at muscarinic acetylcholine receptors M1 – M5 (EC₅₀ in the range of 7-410 nM). May be effective in dementia.

B1824 | Arecoline hydrobromide DataSheet

Alternate Name/Synonyms: 1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxylic acid, methyl ester, hydrobromide

Appearance: White solid

Formulation: N/A

CAS Number: 300-08-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₈H₁₃NO₂ • HBr

Molecular Weight: 236.11

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: H₂O (>50 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A covalent ACAT1 inhibitor

MDL Number: MFCD00039041

PubChem CID: 9301

SMILES: CN1CCC=C(C1)C(=O)OC.Br

InChi: InChI=1S/C8H13NO2.BrH/c1-9-5-3-4-7(6-9)8(10)11-2;/h4H,3,5-6H2,1-2H3;1H

InChi Key: AXOJRQLKMVSHHZ-UHFFFAOYSA-N