ARHGAP17 (T363) polyclonal Antibody | BS3390

ARHGAP17 (T363) polyclonal Antibody | BS3390 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resulting in down regulation of their active form. ARHGAP17 (Rho GTPase activating protein 17), also known as RICH1, WBP15, MST066, MST110, NADRIN, PP4534, RICH1B, MSTP038, MSTP066 or MSTP110, is a ubiquitously expressed peripheral membrane protein whose expression is highest in heart and placenta. ARHGAP17 is involved in the maintenance of tight junctions by regulating the activity of Cdc42, thereby playing a central role in apical polarity of epithelial cells. Containina a BAR domain and a Rho-GAP domain, ARHGAP17 acts as a GTPase activator for the Cdc42 GTPase by converting it to an inactive GDP-bound state. ARHGAP17 may also participate in the Ca2+-dependent regulation of exocytosis by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of cortical actin filaments. ARHGAP17 exists as seven alternative splice variants.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ARHGAP17 (T363) pAb detects endogenous levels of ARHGAP17 protein.

Molecular Weight: ~ 130 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Zinc finger CCCH domain-containing protein 7B; Rotavirus 'X'-associated non-structural protein; RoXaN; ZC3H7B; KIAA1031

Immunogen: Synthetic peptide, corresponding to amino acids 845-905 of Human RoXaN.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: