ARHGAP18 Antibody (Center) [APR15009G]

ARHGAP18 Antibody (Center) [APR15009G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This ARHGAP18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 180-207 amino acids from the Central region of human ARHGAP18.

Cellular Localisation: Cytoplasm.

Molecular Weight: 74977

Clone: Polyclonal

Gene Name: ARHGAP18 (HGNC:21035)

Gene ID: 93663

Function: Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595) . Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702) . Regulates cell shape, spreading, and migration (PubMed:21865595) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Synonyms: Rho GTPase-activating protein 18, MacGAP, Rho-type GTPase-activating protein 18, ARHGAP18 (HGNC:21035)