ARHGEF9 polyclonal Antibody | BS71020

ARHGEF9 polyclonal Antibody | BS71020 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB IHC IF

Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100

Background: ARHGEF9 (Rho guanine nucleotide exchange factor 9), also known as PEM-2 homolog or Collybistin, is a 516 amino acid cytoplasmic protein. ARHGEF9 acts as a guanine nucleotide exchange factor for Cdc42 and promotes formation of Gephyrin clusters by directly interacting with Gephyrin. ARHGEF9 contains one DH (DBL-homology) domain, one PH domain and one SH3 domain. Defects in the gene encoding ARHGEF9 are a believed to be a cause for startle disease with epilepsy (STHEE), also known as hyperekplexia with epilepsy. This disease is a heterogenous neurological disorder characterized by muscular rigidity, particularly in the neonatal period, and a startle response to auditory or tactile stimuli.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ARHGEF9 polyclonal Antibody detects endogenous levels of ARHGEF9 protein.

Molecular Weight: ~ 61 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: PEM2; EIEE8; PEM-2; HPEM-2; COLLYBISTIN;

Immunogen: Recombinant protein of human ARHGEF9.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A