ARIH2 Polyclonal Antibody | E-AB-12985

ARIH2 Polyclonal Antibody | E-AB-12985 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: HT005, all trans retinoic acid inducible RING finger, Ari 2, Ari-2, ARI2, ARI2, Ariadne 2, Ariadne 2 protein homolog, ariadne homolog 2 (Drosophila), ariadne homolog 2, Ariadne RBR E3 ubiquitin protein ligase 2, ARIH 2, Arih2, E3 ubiquitin protein ligase ARIH2, E3 ubiquitin-protein ligase ARIH2, protein ariadne 2 homolog, Protein ariadne-2 homolog, Triad 1, TRIAD1, Triad1 protein, UIP48

Application: WB, ELISA

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Cell Biology, Epigenetics and Nuclear Signaling

Background: TRIAD1, also known as ARIH2 (ariadne homolog 2) or ARI2, is a 493 amino acid protein that contains one IBR-type zinc finger and two RING-type zinc fingers and belongs to the ariadne subfamily of RBR proteins. Localized to the nucleus, TRIAD1 interacts with UBE2L3 and is thought to act as an E3 ubiquitin-protein ligase, functioning to accept ubiquitin from E2 ubiquitin-conjugating enzymes and transfer the acquired ubiquitin residue to target substrates. TRIAD1 is subject to post-translational DNA damage-dependent phosphorylation, probably by ATM or ATR. The gene encoding TRIAD1 maps to human chromosome 3, which houses over 1, 100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci.

Concentration: 0.6 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic peptide of human ARIH2

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 58 kDa

Molecular Weight(Observed): N/A