Aripiprazole | B1186

Aripiprazole is a high affinity dopamine D2 and 5-HT1A receptor partial agonist (Ki values are ~1.64 and 5.59 nM respectively). Also 5-HT2A antagonist (Ki = 8.7 nM). Aripiprazole is a clinically useful neuroleptic and antipsychotic agent. It improves symptoms of psychosis associated with Alzheimer's disease. Aripiprazole blocks cocaine-seeking behavior without affecting other rewarding behaviors in animal models.

Aripiprazole is a high affinity dopamine D2 and 5-HT1A receptor partial agonist (Ki values are ~1.64 and 5.59 nM respectively). Also 5-HT2A antagonist (Ki = 8.7 nM). Aripiprazole is a clinically useful neuroleptic and antipsychotic agent. It improves symptoms of psychosis associated with Alzheimer's disease. Aripiprazole blocks cocaine-seeking behavior without affecting other rewarding behaviors in animal models.

B1186 | Aripiprazole DataSheet

Alternate Name/Synonyms: 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone

Appearance: White solid

Formulation: N/A

CAS Number: 129722-12-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₃H₂₇Cl₂N₃O₂

Molecular Weight: 448.4

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A high affinity dopamine D2 and 5-HT1A receptor partial agonist

MDL Number: MFCD00892072

PubChem CID: 60795

SMILES: C1CC(=O)NC2=C1C=CC(=C2)OCCCCN3CCN(CC3)C4=C(C(=CC=C4)Cl)Cl

InChi: InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)

InChi Key: CEUORZQYGODEFX-UHFFFAOYSA-N