ARMC9 Antibody (N-term) [APR03816G]

ARMC9 Antibody (N-term) [APR03816G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This ARMC9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-124 amino acids from the N-terminal region of human ARMC9.

Cellular Localisation: Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium {ECO:0000250|UniProtKB:Q9D2I5}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole Note=Localized to the proximal region in cilia. Stimulation of Hh signaling leads to redistribution of ARMC9 toward the ciliary tip within 6 hours, follow by a gradual return to its original proximal location (By similarity) . Localizes to the daughter centriole of the primary cilium in RPE1 cells (PubMed:28625504) {ECO:0000250|UniProtKB:Q9D2I5, ECO:0000269|PubMed:28625504}

Molecular Weight: 91819

Clone: Polyclonal

Gene Name: ARMC9 (HGNC:20730)

Gene ID: 80210

Function: Acts as a positive regulator of hedgehog (Hh) signaling (By similarity) . Involved in ciliogenesis (By similarity) . May participate in the trafficking and/or retention of GLI2 and GLI3 proteins at the ciliary tip (By similarity) .

Summary: Tissue Location: Strongly expressed in most melanomas and melanocytes. Weakly expressed in the testis

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: LisH domain-containing protein ARMC9, Melanoma/melanocyte-specific tumor antigen KU-MEL-1, NS21, ARMC9, KIAA1868