ARN-509 | 9535

ARN-509 is a selective and competitive androgen receptor (AR) inhibitor (IC₅₀ = 16 nM). ARN-509 selectively binds the androgen receptor and impairs its nuclear translocation and DNA binding to androgen response elements useful for prostate cancer treatment.

ARN-509 is a selective and competitive androgen receptor (AR) inhibitor (IC₅₀ = 16 nM). ARN-509 selectively binds the androgen receptor and impairs its nuclear translocation and DNA binding to androgen response elements useful for prostate cancer treatment.

9535 | ARN-509 DataSheet

Alternate Name/Synonyms: 4-[7-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-5-yl]-2-fluoro-N-methylbenzamide

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 956104-40-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₁₅F₄N₅O₂S

Molecular Weight: 477.43

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective and competitive androgen receptor (AR) inhibitor

MDL Number: N/A

PubChem CID: 24872560

SMILES: NC(=O)C1=C(C=C(C=C1)N2C(=S)N(C(=O)C23CCC3)C4=CN=C(C(=C4)C(F)(F)F)C#N)F

InChi: InChI=1S/C21H15F4N5O2S/c1-27-17(31)13-4-3-11(8-15(13)22)30-19(33)29(18(32)20(30)5-2-6-20)12-7-14(21(23,24)25)16(9-26)28-10-12/h3-4,7-8,10H,2,5-6H2,1H3,(H,27,31)

InChi Key: HJBWBFZLDZWPHF-UHFFFAOYSA-N