Arrestin 1 (phospho Ser412) Antibody | 79-784

Arrestin 1 (phospho Ser412) Antibody | 79-784 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: N/A

Immunogen: Arrestin 1 (phospho Ser412) antibody was raised against a peptide sequence around phosphorylation site of Serine 412 (T-G-S (p) -P-Q) derived from Human Arrestin 1.

Research Area: Phospho-Specific

Tested Application: WB, IHC

Application: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Specificiy: The antibody detects endogenous levels of Arrestin-1 only when phosphorylated at serine 412.

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: 50 kDa

Validation: N/A

Isoform: N/A

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+) , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Concentration: 1 mg/mL

Storage Condition: Store antibody at -20˚C for up to one year.

Alternate Name: ARR1, arrestin 2, arrestin beta 1, beta-arrestin-1

User Note: N/A

BACKGROUND: Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation.