Artesunate | B2332

Artesunate is a semisynthetic derivative of artemisinin. It acts on the electron transport chain, generates local reactive oxygen species, and causes the depolarization of the mitochondrial membrane. It inhibits TNFα-induced production of proinflammatory cytokines via inhibition of NF-κB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes. Displays cytotoxic action against cancer cell lines of different tumor types. Also induces ferroptosis.

Artesunate is a semisynthetic derivative of artemisinin. It acts on the electron transport chain, generates local reactive oxygen species, and causes the depolarization of the mitochondrial membrane. It inhibits TNFα-induced production of proinflammatory cytokines via inhibition of NF-κB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes. Also induces ferroptosis.

B2332 | Artesunate DataSheet

Alternate Name/Synonyms: WR-256283,NSC-712571,Artesunic acid,butanedioic acid, 1-[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl] ester

Appearance: White to off-white solid

Formulation:

CAS Number: 88495-63-0

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₉H₂₈O₈

Molecular Weight: 384.42

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: >10 mg/ml (DMSO) in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: Artesunate is a semisynthetic derivative of artemisinin

MDL Number: MFCD00866204

PubChem CID: 65664

SMILES: CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)OC(=O)CCC(=O)O)C

InChi: InChI=1S/C19H28O8/c1-10-4-5-13-11(2)16(23-15(22)7-6-14(20)21)24-17-19(13)12(10)8-9-18(3,25-17)26-27-19/h10-13,16-17H,4-9H2,1-3H3,(H,20,21)/t10-,11-,12+,13+,16+,17-,18-,19-/m1/s1

InChi Key: FIHJKUPKCHIPAT-NKHDUEHSSA-N