AS-1517499 | B3357

AS-1517499 | B3357

Description: AS-1517499 is a potent and brain-permeable STAT6 phosphorylation inhibitor (IC50 = 21 nM). It inhibits IL-4-induced Th2 differentiation (IC50 = 2.3 nM), but not IL-12-induced Th1 differentiation, of mouse spleen T cells.

Alternate Name/Synonyms: AS1517499 2-[[2-(3-chloro-4-hydroxyphenyl)ethyl]amino]-4-[(phenylmethyl)amino]-5-pyrimidinecarboxamide

Appearance: Solid

Formulation:

CAS Number: 919486-40-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₂₀ClN₅O₂

Molecular Weight: 397.9

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~15 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Tag Line: A potent Stat6 phosphorylation inhibitor

PubChem CID: 10340781

PubChem CID Link: https://pubchem.ncbi.nlm.nih.gov/compound/10340781

SMILES: OC1=C(Cl)C=C(CCNC2=NC(NCC3=CC=CC=C3)=C(C(N)=O)C=N2)C=C1

InChi: InChI=1S/C20H20ClN5O2/c21-16-10-13(6-7-17(16)27)8-9-23-20-25-12-15(18(22)28)19(26-20)24-11-14-4-2-1-3-5-14/h1-7,10,12,27H,8-9,11H2,(H2,22,28)(H2,23,24,25,26)

InChi Key: OZRMEKAUZBKTTC-UHFFFAOYSA-N

Category: Biochemicals